EXPLAINER
US and Iran continue mediated talks, exchanging draft proposals aimed at reaching a formal agreement.
Published On 22 May 2026
Iran and the United States are continuing mediated talks aimed at ending the conflict, with Iranian media reporting that both sides are exchanging messages and draft proposals to establish a formal framework for an agreement.
Al Jazeera’s correspondent Almigdad Alruhaid reported from Tehran that Pakistani officials were engaged in “intense mediation activity” between the two countries.
The diplomatic push comes as US Secretary of State Marco Rubio said there were “some good signs” for a possible breakthrough. However, US President Donald Trump also warned Washington could take “very drastic” action if Iran refuses to give up its uranium stockpiles.
Here is what we know:
In Iran
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‘War crime’ on medical research centre: Iran has accused the US and Israel of committing a “war crime” by bombing the Pasteur Institute of Iran early in the war, after The Lancet journal warned that the attack severely damaged a key pillar of the country’s public health system.
- Thousands rescued from rubble: The Iranian Red Crescent said its aid workers rescued more than 7,200 people trapped beneath rubble during US and Israeli attacks, sharing footage of survivors being pulled from destroyed buildings for the first time.
War diplomacy
- Nuclear ‘red lines’ must shift: Doug Bandow, a senior fellow at the Cato Institute, said the US and Iran will need to move beyond conflicting “red lines” on Tehran’s nuclear programme for negotiations to make progress. Speaking to Al Jazeera, Bandow said both sides must be willing to compromise and continue serious talks if they want to avoid further escalation and move away from war.
- Rubio sees ‘good signs’ in talks: US Secretary of State Marco Rubio said negotiations with Iran have shown “some progress”, while cautioning that it remains unclear whether a deal can be reached in the coming days. Rubio said President Donald Trump still prefers a diplomatic agreement, but warned Washington has “other options” if talks fail.
- Pakistani mediation efforts intensify in Tehran: Al Jazeera’s Alruhaid said senior Pakistani officials are engaged in “intense mediation activity” in Tehran as efforts accelerate to prevent further escalation. While one senior Iranian official said negotiators were close to a deal and working on draft texts, another source cautioned it was still too early to say whether a final agreement was within reach.
In the US
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US forces at ‘peak readiness’: CENTCOM said the USS Abraham Lincoln strike group remains at “peak readiness” in the Arabian Sea, sharing images of warplanes taking off as Washington maintains pressure on Iran amid ongoing mediation efforts.
- US reportedly suffers major Reaper drone losses: Iran has destroyed more than two dozen MQ-9 Reaper drones operated by US forces since the conflict began, according to Bloomberg News. The reported losses are estimated at $1bn, nearly 20 percent of the Pentagon’s pre-war inventory.
- US pauses Taiwan arms sales: Acting Navy Secretary Hung Cao told a Senate hearing that Washington has paused a $14bn arms sale to Taiwan to ensure the US has enough munitions for its military campaign against Iran, a move Republican Senator Mitch McConnell called “distressing”.
In Lebanon and Palestine
- Israeli strike kills two in southern Lebanon: The Israeli military said it carried out an air raid that killed two people near the Lebanon-Israel border, after detecting what it described as “suspicious movement” in southern Lebanon.
- US sanctions allies of Hezbollah: The US has imposed sanctions on nine people accused of helping Hezbollah undermine Lebanon’s sovereignty and obstruct efforts to disarm the group, including Lebanese politicians, security officials and Iran’s ambassador-designate to Beirut.
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Palestinian envoy condemns aid blockade: Palestine’s UN envoy Riyad Mansour said Israel is continuing to collectively punish more than two million Palestinians through its blockade on aid and ongoing attacks, warning the world must not become “accustomed to seeing Palestinians killed”.
- US urges humane treatment of flotilla detainees: According to Al Jazeera’s Ali Harb, the US State Department said activists detained by Israeli forces after attempting to break the Gaza blockade “must be treated humanely and consistent with international law”, while also reiterating Washington’s opposition to the flotilla movement.